Felodipine and Erythromycin Interaction
Drug interaction information between Felodipine and Erythromycin.
Felodipine and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Felodipine and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down how fast your body gets rid of felodipine. This leads to much higher amounts of felodipine in your system than usual.
FDA Label Information
Co-administration of CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, grapefruit juice, cimetidine) with felodipine may lead to several-fold increases in the plasma levels of felodipine, either due to an increase in bioavailability or due to a decrease in metabolism. Erythromycin Co-administration of felodipine with erythromycin resulted in approximately 2.5-fold increase in the AUC and C max , and about 2-fold prolongation in the half-life of felodipine.
Felodipine Also Interacts With
- Itraconazole major
- Theophylline major
- Nirmatrelvir/Ritonavir moderate
- Metoprolol minor
- Spironolactone minor
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Felodipine + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Felodipine's 18. In the minor band specifically: Felodipine has 15 (also Metoprolol, Spironolactone, Ketoconazole, Digoxin); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Felodipine and Erythromycin?
Erythromycin slows down how fast your body gets rid of felodipine. This leads to much higher amounts of felodipine in your system than usual.
Erythromycin carries more major-labeled pairs than Felodipine
SPL source-record counts only. This page's band is minor · classes on file: Felodipine (Calcium Channel Blocker); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Felodipine's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 15 minor · 18 total
- Other minor peers for Felodipine
- Metoprolol
- Spironolactone
- Ketoconazole
- Digoxin
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.