Felodipine and Ketoconazole Interaction
Drug interaction information between Felodipine and Ketoconazole.
Felodipine and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Felodipine and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole blocks the enzyme that breaks down felodipine. This can cause felodipine levels to rise significantly in your blood.
FDA Label Information
Co-administration of CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, grapefruit juice, cimetidine) with felodipine may lead to several-fold increases in the plasma levels of felodipine, either due to an increase in bioavailability or due to a decrease in metabolism.
Felodipine Also Interacts With
- Itraconazole major
- Theophylline major
- Nirmatrelvir/Ritonavir moderate
- Metoprolol minor
- Spironolactone minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Felodipine + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Felodipine's 18. In the minor band specifically: Felodipine has 15 (also Metoprolol, Spironolactone, Erythromycin, Digoxin); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Felodipine and Ketoconazole?
Ketoconazole blocks the enzyme that breaks down felodipine. This can cause felodipine levels to rise significantly in your blood.
Ketoconazole carries more major-labeled pairs than Felodipine
SPL source-record counts only. This page's band is minor · classes on file: Felodipine (Calcium Channel Blocker); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Felodipine's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 15 minor · 18 total
- Other minor peers for Felodipine
- Metoprolol
- Spironolactone
- Erythromycin
- Digoxin
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.