Felodipine and Spironolactone Interaction
Drug interaction information between Felodipine and Spironolactone.
Felodipine and Spironolactone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Felodipine and Spironolactone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is no significant interaction between these two drugs. They do not interfere with how each other works in the body.
FDA Label Information
Other Concomitant Therapy In healthy subjects there were no clinically significant interactions when felodipine was given concomitantly with indomethacin or spironolactone.
Felodipine Also Interacts With
- Itraconazole major
- Theophylline major
- Nirmatrelvir/Ritonavir moderate
- Metoprolol minor
- Ketoconazole minor
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Felodipine + Spironolactone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Felodipine's 18. In the minor band specifically: Felodipine has 15 (also Metoprolol, Ketoconazole, Erythromycin, Digoxin); Spironolactone has 14 (also Digoxin, Cholestyramine, Amlodipine/Valsartan, Enalapril).
What mechanism field is on file for Felodipine and Spironolactone?
There is no significant interaction between these two drugs. They do not interfere with how each other works in the body.
Felodipine carries more major-labeled pairs than Spironolactone
SPL source-record counts only. This page's band is minor · classes on file: Felodipine (Calcium Channel Blocker); Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist).
Felodipine has 2 major-labeled pairs vs Spironolactone's 0. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 15 minor · 18 total
- Other minor peers for Felodipine
- Metoprolol
- Ketoconazole
- Erythromycin
- Digoxin
0 major · 9 moderate · 14 minor · 23 total
- Other minor peers for Spironolactone
- Digoxin
- Cholestyramine
- Amlodipine/Valsartan
- Enalapril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.