Felodipine and Spironolactone Interaction
Drug interaction information between Felodipine and Spironolactone.
Felodipine and Spironolactone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Felodipine and Spironolactone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
There is no significant interaction between these two drugs. They do not interfere with how each other works in the body.
What To Do
No special changes are usually needed when taking these two drugs together. Continue taking your medications as prescribed.
FDA Label Information
Other Concomitant Therapy In healthy subjects there were no clinically significant interactions when felodipine was given concomitantly with indomethacin or spironolactone.
Felodipine Also Interacts With
- Itraconazole major
- Theophylline major
- Nirmatrelvir/Ritonavir moderate
- Metoprolol minor
- Ketoconazole minor
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
Can I take Felodipine and Spironolactone together?
This is a minor interaction. No special changes are usually needed when taking these two drugs together. Continue taking your medications as prescribed.
How serious is the interaction between Felodipine and Spironolactone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Felodipine and Spironolactone interact?
There is no significant interaction between these two drugs. They do not interfere with how each other works in the body.
Understanding the Felodipine and Spironolactone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Felodipine belongs to the Calcium Channel Blocker class and Spironolactone belongs to the Potassium-Sparing Diuretic / Aldosterone Antagonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: There is no significant interaction between these two drugs. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Felodipine has 18 total documented interactions on file in this dataset, and Spironolactone has 23. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No special changes are usually needed when taking these two drugs together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Felodipine or Spironolactone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.