Erythromycin and Risperidone Interaction
Drug interaction information between Erythromycin and Risperidone.
Erythromycin and Risperidone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Erythromycin and Risperidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin can slightly change how your body processes risperidone, but the effect is too small to matter.
FDA Label Information
Dose adjustment is not recommended for risperidone tablets when co-administered with ranitidine, cimetidine, amitriptyline, or erythromycin [see Table 18 ] . Do not exceed twice the patient’s usual dose Enzyme (CYP3A) inhibitors Ranitidine 150 mg twice daily 1 mg single dose 1.2 1.4 Dose adjustment not needed Cimetidine 400 mg twice daily 1 mg single dose 1.1 1.3 Dose adjustment not needed Erythromycin 500 mg four times daily 1 mg single dose 1.1 0.94 Dose adjustment not needed Other Drugs Amitriptyline 50 mg twice daily 3 mg twice daily 1.2 1.1 Dose adjustment not Needed *Change relative...
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Sildenafil major
- Lefamulin moderate
- Lovastatin moderate
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Lithium major
- Ranitidine major
- Cimetidine major
Frequently Asked Questions
What SPL severity band is on file for Erythromycin + Risperidone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Risperidone's 20. In the major band specifically: Erythromycin has 4 (also Eplerenone, Pitavastatin, Sildenafil); Risperidone has 6 (also Amitriptyline, Carbamazepine, Lithium, Ranitidine).
What mechanism field is on file for Erythromycin and Risperidone?
Erythromycin can slightly change how your body processes risperidone, but the effect is too small to matter.
Risperidone carries more major-labeled pairs than Erythromycin
SPL source-record counts only. This page's band is major · classes on file: Erythromycin (Macrolide Antibiotic); Risperidone (Atypical Antipsychotic).
Risperidone has 6 major-labeled pairs vs Erythromycin's 4.
4 major · 6 moderate · 53 minor · 63 total
- Other major peers for Erythromycin
- Eplerenone
- Pitavastatin
- Sildenafil
6 major · 5 moderate · 9 minor · 20 total
- Other major peers for Risperidone
- Amitriptyline
- Carbamazepine
- Lithium
- Ranitidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.