Erythromycin and Acetaminophen/Oxycodone Interaction
Drug interaction information between Erythromycin and Acetaminophen/Oxycodone.
Erythromycin and Acetaminophen/Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Erythromycin and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin blocks the enzymes that normally clear the pain medicine from your body, which can cause the drug to build up to high levels in your blood.
FDA Label Information
Drug Interactions Inhibitors of CYP3A4 and CYP2D6 The concomitant use of PERCOCET and CYP3A4 inhibitors, such as macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g.
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Erythromycin + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Acetaminophen/Oxycodone's 23. In the minor band specifically: Erythromycin has 53 (also Alprazolam, Atorvastatin, Bromocriptine, Buprenorphine); Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Cyclobenzaprine, Oxycodone).
What mechanism field is on file for Erythromycin and Acetaminophen/Oxycodone?
Erythromycin blocks the enzymes that normally clear the pain medicine from your body, which can cause the drug to build up to high levels in your blood.
Erythromycin carries more major-labeled pairs than Acetaminophen/Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Erythromycin (Macrolide Antibiotic); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
Erythromycin has 4 major-labeled pairs vs Acetaminophen/Oxycodone's 0. This page itself is in the minor band, not the major band.
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Alprazolam
- Atorvastatin
- Bromocriptine
- Buprenorphine
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.