Erythromycin and Atorvastatin Interaction
Drug interaction information between Erythromycin and Atorvastatin.
Erythromycin and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Erythromycin and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down the process of clearing atorvastatin from your system, leading to higher drug levels.
FDA Label Information
Examples: Erythromycin, clarithromycin, itraconazole, ketoconazole, posaconazole, and voriconazole.
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Erythromycin + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Bromocriptine, Buprenorphine); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Rifampin).
What mechanism field is on file for Erythromycin and Atorvastatin?
Erythromycin slows down the process of clearing atorvastatin from your system, leading to higher drug levels.
Erythromycin carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is minor · classes on file: Erythromycin (Macrolide Antibiotic); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Erythromycin has 4 major-labeled pairs vs Atorvastatin's 3. This page itself is in the minor band, not the major band.
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Bromocriptine
- Buprenorphine
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.