Felodipine and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Felodipine and Nirmatrelvir/Ritonavir.
Felodipine and Nirmatrelvir/Ritonavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Felodipine and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination slows down the removal of felodipine from your body, which can cause your blood pressure to drop too low.
FDA Label Information
Calcium channel blockers amlodipine, diltiazem, felodipine, nicardipine, nifedipine, verapamil ↑ calcium channel blocker Caution is warranted and clinical monitoring of patients is recommended.
Felodipine Also Interacts With
- Itraconazole major
- Theophylline major
- Metoprolol minor
- Spironolactone minor
- Ketoconazole minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Felodipine + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Felodipine's 18. In the moderate band specifically: Felodipine has 1; Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban).
What mechanism field is on file for Felodipine and Nirmatrelvir/Ritonavir?
This combination slows down the removal of felodipine from your body, which can cause your blood pressure to drop too low.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Felodipine
SPL source-record counts only. This page's band is moderate · classes on file: Felodipine (Calcium Channel Blocker); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Felodipine's 2. This page itself is in the moderate band, not the major band.
2 major · 1 moderate · 15 minor · 18 total
Felodipine has no other moderate-band peer in this dataset besides Nirmatrelvir/Ritonavir.
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.