Erythromycin and Lefamulin Interaction
Drug interaction information between Erythromycin and Lefamulin.
Erythromycin and Lefamulin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Erythromycin and Lefamulin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs can both interfere with the electrical signals that control your heartbeat. Using them at the same time makes a dangerous heart rhythm more likely.
What To Do
You should avoid taking these two drugs together. Ask your doctor for a different antibiotic that does not carry this risk.
FDA Label Information
Therefore, avoid concomitant use of XENLETA Injection and XENLETA Tablets with such drugs (for example, Class IA and III antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, tricyclic antidepressants).
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lovastatin moderate
Lefamulin Also Interacts With
- Moxifloxacin moderate
- Simvastatin minor
- Alprazolam minor
- Diltiazem minor
- Verapamil minor
Frequently Asked Questions
Can I take Erythromycin and Lefamulin together?
This is a moderate interaction. You should avoid taking these two drugs together. Ask your doctor for a different antibiotic that does not carry this risk.
How serious is the interaction between Erythromycin and Lefamulin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Erythromycin and Lefamulin interact?
These two drugs can both interfere with the electrical signals that control your heartbeat. Using them at the same time makes a dangerous heart rhythm more likely.
Understanding the Erythromycin and Lefamulin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Erythromycin belongs to the Macrolide Antibiotic class and Lefamulin belongs to the Pleuromutilin Antibiotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs can both interfere with the electrical signals that control your heartbeat. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Erythromycin has 63 total documented interactions on file in this dataset, and Lefamulin has 7. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should avoid taking these two drugs together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Erythromycin or Lefamulin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.