Erythromycin and Alprazolam Interaction
Drug interaction information between Erythromycin and Alprazolam.
Erythromycin and Alprazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Erythromycin and Alprazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down how fast your body gets rid of alprazolam. This can lead to higher levels of the drug in your blood and increase the risk of side effects.
FDA Label Information
Examples Nefazodone, fluvoxamine, cimetidine, erythromycin CYP3A Inducers Clinical implication Concomitant use of CYP3A inducers can increase alprazolam metabolism and therefore can decease plasma levels of alprazolam [see Clinical Pharmacology (12.3) ] .
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Frequently Asked Questions
What SPL severity band is on file for Erythromycin + Alprazolam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Alprazolam's 27. In the minor band specifically: Erythromycin has 53 (also Acetaminophen/Oxycodone, Atorvastatin, Bromocriptine, Buprenorphine); Alprazolam has 20 (also Tramadol, Oxycodone, Morphine, Carbamazepine).
What mechanism field is on file for Erythromycin and Alprazolam?
Erythromycin slows down how fast your body gets rid of alprazolam. This can lead to higher levels of the drug in your blood and increase the risk of side effects.
Erythromycin carries more major-labeled pairs than Alprazolam
SPL source-record counts only. This page's band is minor · classes on file: Erythromycin (Macrolide Antibiotic); Alprazolam (Benzodiazepine).
Erythromycin has 4 major-labeled pairs vs Alprazolam's 0. This page itself is in the minor band, not the major band.
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Atorvastatin
- Bromocriptine
- Buprenorphine
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Oxycodone
- Morphine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.