Erythromycin and Sildenafil Interaction
Drug interaction information between Erythromycin and Sildenafil.
Erythromycin and Sildenafil have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Erythromycin and Sildenafil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin prevents your body from processing sildenafil normally, which increases the amount of medicine in your blood.
FDA Label Information
7 DRUG INTERACTIONS Sildenafil can potentiate the hypotensive effects of nitrates, alpha blockers, and anti-hypertensives ( 4.1 , 5.5 , 7.1 , 7.2 , 7.3 , 12.2 ) With concomitant use of alpha blockers, initiate sildenafil at 25 mg dose ( 2.3 ) CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, erythromycin): Increase sildenafil exposure ( 2.4 , 7.4 , 12.3 ) Ritonavir: Do not exceed a maximum single dose of 25 mg in a 48 hour period ( 2.4 , 5.6 ) Erythromycin or strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, saquinavir): Consider a starting dose of 25 mg ( 2.4 , 7.4...
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Lefamulin moderate
- Lovastatin moderate
Sildenafil Also Interacts With
- Ketoconazole major
- Itraconazole major
- Darunavir major
- Hydralazine/Isosorbide Dinitrate major
- Nirmatrelvir/Ritonavir major
Frequently Asked Questions
What SPL severity band is on file for Erythromycin + Sildenafil?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Sildenafil's 10. In the major band specifically: Erythromycin has 4 (also Eplerenone, Pitavastatin, Risperidone); Sildenafil has 6 (also Ketoconazole, Itraconazole, Darunavir, Hydralazine).
What mechanism field is on file for Erythromycin and Sildenafil?
Erythromycin prevents your body from processing sildenafil normally, which increases the amount of medicine in your blood.
Sildenafil carries more major-labeled pairs than Erythromycin
SPL source-record counts only. This page's band is major · classes on file: Erythromycin (Macrolide Antibiotic); Sildenafil (PDE5 Inhibitor).
Sildenafil has 6 major-labeled pairs vs Erythromycin's 4.
4 major · 6 moderate · 53 minor · 63 total
- Other major peers for Erythromycin
- Eplerenone
- Pitavastatin
- Risperidone
6 major · 1 moderate · 3 minor · 10 total
- Other major peers for Sildenafil
- Ketoconazole
- Itraconazole
- Darunavir
- Hydralazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.