Felodipine and Metoprolol Interaction
Drug interaction information between Felodipine and Metoprolol.
Felodipine and Metoprolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Felodipine and Metoprolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Felodipine can increase the amount of metoprolol that stays in your blood. This happens because felodipine changes how the body processes metoprolol.
FDA Label Information
Beta-Blocking Agents A pharmacokinetic study of felodipine in conjunction with metoprolol demonstrated no significant effects on the pharmacokinetics of felodipine. The AUC and C max of metoprolol, however, were increased approximately 31 and 38%, respectively. In controlled clinical trials, however, beta-blockers including metoprolol were concurrently administered with felodipine and were well tolerated.
Felodipine Also Interacts With
- Itraconazole major
- Theophylline major
- Nirmatrelvir/Ritonavir moderate
- Spironolactone minor
- Ketoconazole minor
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Felodipine + Metoprolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Felodipine and Metoprolol tie at 18 labeled pairs each. minor-band counts: Felodipine 15 alongside Spironolactone, Ketoconazole, Erythromycin, Digoxin; Metoprolol 14 alongside Fluoxetine, Paroxetine, Propafenone, Epinephrine.
What mechanism field is on file for Felodipine and Metoprolol?
Felodipine can increase the amount of metoprolol that stays in your blood. This happens because felodipine changes how the body processes metoprolol.
Felodipine carries more major-labeled pairs than Metoprolol
SPL source-record counts only. This page's band is minor · classes on file: Felodipine (Calcium Channel Blocker); Metoprolol (Beta-Blocker).
Felodipine has 2 major-labeled pairs vs Metoprolol's 1. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 15 minor · 18 total
- Other minor peers for Felodipine
- Spironolactone
- Ketoconazole
- Erythromycin
- Digoxin
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Fluoxetine
- Paroxetine
- Propafenone
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.