Felodipine and Digoxin Interaction
Drug interaction information between Felodipine and Digoxin.
Felodipine and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Felodipine and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Felodipine does not have a major effect on how the body processes digoxin. These drugs do not interfere with each other in a meaningful way.
FDA Label Information
Digoxin When given concomitantly with felodipine extended-release the pharmacokinetics of digoxin in patients with heart failure were not significantly altered.
Felodipine Also Interacts With
- Itraconazole major
- Theophylline major
- Nirmatrelvir/Ritonavir moderate
- Metoprolol minor
- Spironolactone minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Felodipine + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Felodipine's 18. In the minor band specifically: Felodipine has 15 (also Metoprolol, Spironolactone, Ketoconazole, Erythromycin); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Felodipine and Digoxin?
Felodipine does not have a major effect on how the body processes digoxin. These drugs do not interfere with each other in a meaningful way.
Digoxin's labeled portfolio outnumbers Felodipine
SPL source-record counts only. This page's band is minor · classes on file: Felodipine (Calcium Channel Blocker); Digoxin (Cardiac Glycoside).
2 major · 1 moderate · 15 minor · 18 total
- Other minor peers for Felodipine
- Metoprolol
- Spironolactone
- Ketoconazole
- Erythromycin
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.