Felodipine and Itraconazole Interaction
Drug interaction information between Felodipine and Itraconazole.
Felodipine and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Felodipine and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole stops the body from breaking down felodipine, which can lead to dangerously high levels of the blood pressure medicine in your system.
FDA Label Information
Calcium Channel Blockers Felodipine a Nisoldipine Contraindicated during and 2 weeks after itraconazole treatment.
Felodipine Also Interacts With
- Theophylline major
- Nirmatrelvir/Ritonavir moderate
- Metoprolol minor
- Spironolactone minor
- Ketoconazole minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Felodipine + Itraconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Felodipine's 18. In the major band specifically: Felodipine has 2 (also Theophylline); Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone).
What mechanism field is on file for Felodipine and Itraconazole?
Itraconazole stops the body from breaking down felodipine, which can lead to dangerously high levels of the blood pressure medicine in your system.
Itraconazole carries more major-labeled pairs than Felodipine
SPL source-record counts only. This page's band is major · classes on file: Felodipine (Calcium Channel Blocker); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Felodipine's 2.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.