Atorvastatin and Itraconazole Interaction
Drug interaction information between Atorvastatin and Itraconazole.
Atorvastatin and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Atorvastatin and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole prevents your body from breaking down atorvastatin normally, which increases the amount of medicine in your bloodstream.
FDA Label Information
Intervention: In patients taking clarithromycin or itraconazole, do not exceed atorvastatin 20 mg [see Dosage and Administration (2.5) ]. Examples: Erythromycin, clarithromycin, itraconazole, ketoconazole, posaconazole, and voriconazole.
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Cyclosporine moderate
- Colchicine moderate
- Gemfibrozil moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Itraconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Atorvastatin's 36. In the major band specifically: Atorvastatin has 3 (also Clarithromycin, Darunavir); Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone).
What mechanism field is on file for Atorvastatin and Itraconazole?
Itraconazole prevents your body from breaking down atorvastatin normally, which increases the amount of medicine in your bloodstream.
Itraconazole carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is major · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Atorvastatin's 3.
3 major · 8 moderate · 25 minor · 36 total
- Other major peers for Atorvastatin
- Clarithromycin
- Darunavir
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.