Atorvastatin and Itraconazole Interaction
Drug interaction information between Atorvastatin and Itraconazole.
Atorvastatin and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Atorvastatin and Itraconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Itraconazole prevents your body from breaking down atorvastatin normally, which increases the amount of medicine in your bloodstream.
What To Do
Do not take more than 20 mg of atorvastatin each day if you are also using itraconazole.
FDA Label Information
Intervention: In patients taking clarithromycin or itraconazole, do not exceed atorvastatin 20 mg [see Dosage and Administration (2.5) ]. Examples: Erythromycin, clarithromycin, itraconazole, ketoconazole, posaconazole, and voriconazole.
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Cyclosporine moderate
- Colchicine moderate
- Gemfibrozil moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
Can I take Atorvastatin and Itraconazole together?
This is a major interaction. Do not take more than 20 mg of atorvastatin each day if you are also using itraconazole.
How serious is the interaction between Atorvastatin and Itraconazole?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Atorvastatin and Itraconazole interact?
Itraconazole prevents your body from breaking down atorvastatin normally, which increases the amount of medicine in your bloodstream.
Understanding the Atorvastatin and Itraconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Atorvastatin belongs to the HMG-CoA Reductase Inhibitor (Statin) class and Itraconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Itraconazole prevents your body from breaking down atorvastatin normally, which increases the amount of medicine in your bloodstream. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Atorvastatin has 36 total documented interactions on file in this dataset, and Itraconazole has 116. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not take more than 20 mg of atorvastatin each day if you are also using itraconazole. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Atorvastatin or Itraconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.