Atorvastatin and Colchicine Interaction
Drug interaction information between Atorvastatin and Colchicine.
Atorvastatin and Colchicine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Atorvastatin and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause muscle damage, and taking them together increases the risk of a severe muscle breakdown.
FDA Label Information
Colchicine Clinical Impact: Cases of myopathy and rhabdomyolysis have been reported with concomitant use of colchicine with atorvastatin. Intervention: Consider the risk/benefit of concomitant use of colchicine with atorvastatin.
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Gemfibrozil moderate
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ezetimibe moderate
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Colchicine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Colchicine's 28. In the moderate band specifically: Atorvastatin has 8 (also Cyclosporine, Gemfibrozil, Niacin, Fluconazole); Colchicine has 9 (also Ezetimibe, Ezetimibe/Simvastatin, Fenofibrate, Pitavastatin).
What mechanism field is on file for Atorvastatin and Colchicine?
Both drugs can cause muscle damage, and taking them together increases the risk of a severe muscle breakdown.
Colchicine carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Colchicine (Anti-Gout Agent).
Colchicine has 4 major-labeled pairs vs Atorvastatin's 3. This page itself is in the moderate band, not the major band.
3 major · 8 moderate · 25 minor · 36 total
- Other moderate peers for Atorvastatin
- Cyclosporine
- Gemfibrozil
- Niacin
- Fluconazole
4 major · 9 moderate · 15 minor · 28 total
- Other moderate peers for Colchicine
- Ezetimibe
- Ezetimibe/Simvastatin
- Fenofibrate
- Pitavastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.