Atorvastatin and Rifampin Interaction
Drug interaction information between Atorvastatin and Rifampin.
Atorvastatin and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atorvastatin and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up how fast your body gets rid of atorvastatin, which can make the statin less effective.
FDA Label Information
Rifampin: May reduce atorvastatin plasma concentrations. Table 3: Drug Interactions that may Decrease Exposure to Atorvastatin Rifampin Clinical Impact: Concomitant administration of atorvastatin with rifampin, an inducer of cytochrome P450 3A4 and inhibitor of OATP1B1, can lead to variable reductions in plasma concentrations of atorvastatin. Due to the dual interaction mechanism of rifampin, delayed administration of atorvastatin after administration of rifampin has been associated with a significant reduction in atorvastatin plasma concentrations.
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Atorvastatin and Rifampin?
Rifampin speeds up how fast your body gets rid of atorvastatin, which can make the statin less effective.
Rifampin carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is minor · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Atorvastatin's 3. This page itself is in the minor band, not the major band.
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.