Atorvastatin and Darunavir Interaction
Drug interaction information between Atorvastatin and Darunavir.
Atorvastatin and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Atorvastatin and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir interferes with the enzymes that clear atorvastatin from your system, potentially leading to side effects from too much medicine.
FDA Label Information
In patients taking saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, fosamprenavir plus ritonavir, elbasvir plus grazoprevir or letermovir, do not exceed atorvastatin 20 mg. Examples: Tipranavir plus ritonavir, glecaprevir plus pibrentasvir, lopinavir plus ritonavir, simeprevir, saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, fosamprenavir plus ritonavir, elbasvir plus grazoprevir, letermovir, nelfinavir, and ledipasvir plus sofosbuvir.
Atorvastatin Also Interacts With
- Clarithromycin major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
- Gemfibrozil moderate
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Atorvastatin's 36. In the major band specifically: Atorvastatin has 3 (also Clarithromycin, Itraconazole); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide).
What mechanism field is on file for Atorvastatin and Darunavir?
Darunavir interferes with the enzymes that clear atorvastatin from your system, potentially leading to side effects from too much medicine.
Darunavir carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is major · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Atorvastatin's 3.
3 major · 8 moderate · 25 minor · 36 total
- Other major peers for Atorvastatin
- Clarithromycin
- Itraconazole
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.