Erythromycin and Buprenorphine Interaction
Drug interaction information between Erythromycin and Buprenorphine.
Erythromycin and Buprenorphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Erythromycin and Buprenorphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin blocks the enzyme that clears buprenorphine from your system. This can lead to higher levels of the drug in your body.
FDA Label Information
Examples: Macrolide antibiotics (e.g., erythromycin), azole-antifungal agents (e.g.
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Buprenorphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Erythromycin + Buprenorphine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Buprenorphine's 29. In the minor band specifically: Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine); Buprenorphine has 28 (also Trazodone, Cyclobenzaprine, Mirtazapine, Ketoconazole).
What mechanism field is on file for Erythromycin and Buprenorphine?
Erythromycin blocks the enzyme that clears buprenorphine from your system. This can lead to higher levels of the drug in your body.
Erythromycin carries more major-labeled pairs than Buprenorphine
SPL source-record counts only. This page's band is minor · classes on file: Erythromycin (Macrolide Antibiotic); Buprenorphine (Partial Opioid Agonist).
Erythromycin has 4 major-labeled pairs vs Buprenorphine's 0. This page itself is in the minor band, not the major band.
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
0 major · 1 moderate · 28 minor · 29 total
- Other minor peers for Buprenorphine
- Trazodone
- Cyclobenzaprine
- Mirtazapine
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.