Atorvastatin and Cyclosporine Interaction
Drug interaction information between Atorvastatin and Cyclosporine.
Atorvastatin and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Atorvastatin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine stops your body from breaking down and removing atorvastatin, which can lead to very high levels of the drug in your blood. This increases the risk of severe muscle breakdown.
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Colchicine moderate
- Gemfibrozil moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Atorvastatin's 36. In the moderate band specifically: Atorvastatin has 8 (also Colchicine, Gemfibrozil, Niacin, Fluconazole); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Atorvastatin and Cyclosporine?
Cyclosporine stops your body from breaking down and removing atorvastatin, which can lead to very high levels of the drug in your blood. This increases the risk of severe muscle breakdown.
Cyclosporine carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Atorvastatin's 3. This page itself is in the moderate band, not the major band.
3 major · 8 moderate · 25 minor · 36 total
- Other moderate peers for Atorvastatin
- Colchicine
- Gemfibrozil
- Niacin
- Fluconazole
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.