Atorvastatin and Estradiol Interaction
Drug interaction information between Atorvastatin and Estradiol.
Atorvastatin and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atorvastatin and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Atorvastatin can cause the body to keep more of the birth control hormone in the blood than usual.
FDA Label Information
Oral Contraceptives: May increase plasma levels of norethindrone and ethinyl estradiol; consider this effect when selecting an oral contraceptive (7.3 ). Table 4: Atorvastatin Effects on Other Drugs Oral Contraceptives Clinical Impact: Co-administration of atorvastatin and an oral contraceptive increased plasma concentrations of norethindrone and ethinyl estradiol [see Clinical Pharmacology (12.3) ].
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Atorvastatin has 25 (also Norethindrone, Ketoconazole, Erythromycin, Rifampin); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Atorvastatin and Estradiol?
Atorvastatin can cause the body to keep more of the birth control hormone in the blood than usual.
Atorvastatin carries more major-labeled pairs than Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Estradiol (Estrogen Hormone).
Atorvastatin has 3 major-labeled pairs vs Estradiol's 1. This page itself is in the minor band, not the major band.
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Norethindrone
- Ketoconazole
- Erythromycin
- Rifampin
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.