Atorvastatin and Ketoconazole Interaction
Drug interaction information between Atorvastatin and Ketoconazole.
Atorvastatin and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atorvastatin and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole blocks the enzymes that break down atorvastatin, which can cause the statin to build up in your body.
FDA Label Information
Examples: Erythromycin, clarithromycin, itraconazole, ketoconazole, posaconazole, and voriconazole.
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Atorvastatin + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Atorvastatin has 25 (also Estradiol, Norethindrone, Erythromycin, Rifampin); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Atorvastatin and Ketoconazole?
Ketoconazole blocks the enzymes that break down atorvastatin, which can cause the statin to build up in your body.
Ketoconazole carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is minor · classes on file: Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Atorvastatin's 3. This page itself is in the minor band, not the major band.
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Erythromycin
- Rifampin
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.