Clonidine and Amiodarone Interaction
Drug interaction information between Clonidine and Amiodarone.
Clonidine and Amiodarone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clonidine and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs slow down the heart rate. Taking them together can make the heart beat too slowly or cause it to stop momentarily.
FDA Label Information
Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Clonidine + Amiodarone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Clonidine's 29. In the minor band specifically: Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol); Amiodarone has 29 (also Atorvastatin, Diltiazem, Verapamil, Cyclosporine).
What mechanism field is on file for Clonidine and Amiodarone?
Both drugs slow down the heart rate. Taking them together can make the heart beat too slowly or cause it to stop momentarily.
Amiodarone carries more major-labeled pairs than Clonidine
SPL source-record counts only. This page's band is minor · classes on file: Clonidine (Central Alpha-2 Agonist); Amiodarone (Class III Antiarrhythmic).
Amiodarone has 4 major-labeled pairs vs Clonidine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Diltiazem
- Verapamil
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.