Clonidine and Repaglinide Interaction
Drug interaction information between Clonidine and Repaglinide.
Clonidine and Repaglinide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clonidine and Repaglinide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clonidine can hide the warning signs of low blood sugar and may also cause blood sugar to drop further when taken with repaglinide.
FDA Label Information
Examples: beta-blockers, clonidine, guanethidine, and reserpine Clopidogrel : Avoid concomitant use; if used concomitantly initiate at 0.5 mg before each meal and limit total daily dose to 4 mg (7) Cyclosporine : Limit daily dose of repaglinide to 6 mg and increase frequency of glucose monitoring when co-administered (7) CYP2C8 and CYP3A4 Inhibitors and Drugs That May Increase the Risk of Hypoglycemia : Co-administration may require repaglinide dose reductions and increased frequency of glucose monitoring (7) CYP2C8 and CYP3A4 Inducers and Drugs That May Decrease the Blood Glucose Lowering...
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Sotalol moderate
- Amitriptyline minor
- Diltiazem minor
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Cyclosporine moderate
- Rifampin moderate
- Albuterol minor
Frequently Asked Questions
What SPL severity band is on file for Clonidine + Repaglinide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Repaglinide's 22. In the moderate band specifically: Clonidine has 4 (also Carvedilol, Metoprolol, Sotalol); Repaglinide has 3 (also Cyclosporine, Rifampin).
What mechanism field is on file for Clonidine and Repaglinide?
Clonidine can hide the warning signs of low blood sugar and may also cause blood sugar to drop further when taken with repaglinide.
Repaglinide carries more major-labeled pairs than Clonidine
SPL source-record counts only. This page's band is moderate · classes on file: Clonidine (Central Alpha-2 Agonist); Repaglinide (Meglitinide).
Repaglinide has 2 major-labeled pairs vs Clonidine's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 25 minor · 29 total
- Other moderate peers for Clonidine
- Carvedilol
- Metoprolol
- Sotalol
2 major · 3 moderate · 17 minor · 22 total
- Other moderate peers for Repaglinide
- Cyclosporine
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.