Clonidine and Amitriptyline Interaction
Drug interaction information between Clonidine and Amitriptyline.
Clonidine and Amitriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clonidine and Amitriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs may work together to cause damage to the clear front part of the eye.
FDA Label Information
Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats (see Toxicology ). In combination with amitriptyline, clonidine hydrochloride administration led to the development of corneal lesions in rats within 5 days.
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Diltiazem minor
Amitriptyline Also Interacts With
- Risperidone major
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Disulfiram minor
Frequently Asked Questions
What SPL severity band is on file for Clonidine + Amitriptyline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Amitriptyline's 21. In the minor band specifically: Clonidine has 25 (also Diltiazem, Verapamil, Haloperidol, Amiodarone); Amitriptyline has 20 (also Sertraline, Fluoxetine, Paroxetine, Disulfiram).
What mechanism field is on file for Clonidine and Amitriptyline?
These drugs may work together to cause damage to the clear front part of the eye.
Amitriptyline carries more major-labeled pairs than Clonidine
SPL source-record counts only. This page's band is minor · classes on file: Clonidine (Central Alpha-2 Agonist); Amitriptyline (Tricyclic Antidepressant (TCA)).
Amitriptyline has 1 major-labeled pair vs Clonidine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Diltiazem
- Verapamil
- Haloperidol
- Amiodarone
1 major · 0 moderate · 20 minor · 21 total
- Other minor peers for Amitriptyline
- Sertraline
- Fluoxetine
- Paroxetine
- Disulfiram
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.