Amiodarone and Simvastatin Interaction
Drug interaction information between Amiodarone and Simvastatin.
Amiodarone and Simvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Amiodarone and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiodarone interferes with how your body breaks down simvastatin, leading to higher levels of the medicine in your blood. This makes muscle damage more likely to happen.
FDA Label Information
Amiodarone, Dronedarone, Ranolazine, or Calcium Channel Blockers Clinical Impact: The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with ezetimibe and simvastatin. For patients taking amiodarone, amlodipine, or ranolazine, do not exceed ezetimibe and simvastatin 10 mg/20 mg daily [see Dosage and Administration ( 2.3 )].
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Lithium moderate
- Clarithromycin moderate
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Dronedarone major
- Ranolazine major
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Simvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Simvastatin's 41. In the major band specifically: Amiodarone has 4 (also Ezetimibe, Ezetimibe/Simvastatin, Nirmatrelvir/Ritonavir); Simvastatin has 11 (also Diltiazem, Verapamil, Cyclosporine, Dronedarone).
What mechanism field is on file for Amiodarone and Simvastatin?
Amiodarone interferes with how your body breaks down simvastatin, leading to higher levels of the medicine in your blood. This makes muscle damage more likely to happen.
Simvastatin carries more major-labeled pairs than Amiodarone
SPL source-record counts only. This page's band is major · classes on file: Amiodarone (Class III Antiarrhythmic); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Amiodarone's 4.
4 major · 9 moderate · 29 minor · 42 total
- Other major peers for Amiodarone
- Ezetimibe
- Ezetimibe/Simvastatin
- Nirmatrelvir/Ritonavir
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Dronedarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.