Clonidine and Verapamil Interaction
Drug interaction information between Clonidine and Verapamil.
Clonidine and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clonidine and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs at the same time can cause a very slow heart rate that might require a hospital stay.
FDA Label Information
Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concomitantly with diltiazem or verapamil.
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Clonidine + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Clonidine's 29. In the minor band specifically: Clonidine has 25 (also Amitriptyline, Diltiazem, Haloperidol, Amiodarone); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Clonidine and Verapamil?
Using these two drugs at the same time can cause a very slow heart rate that might require a hospital stay.
Verapamil carries more major-labeled pairs than Clonidine
SPL source-record counts only. This page's band is minor · classes on file: Clonidine (Central Alpha-2 Agonist); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Clonidine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Haloperidol
- Amiodarone
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.