Amiodarone and Lithium Interaction
Drug interaction information between Amiodarone and Lithium.
Amiodarone and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amiodarone and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can affect the electrical rhythm of your heart. Taking them together increases the risk of a dangerous and irregular heartbeat.
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Clarithromycin moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amlodipine/Valsartan moderate
- Azilsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Amiodarone's 42. In the moderate band specifically: Amiodarone has 9 (also Clarithromycin, Fluconazole, Ledipasvir/Sofosbuvir, Lovastatin); Lithium has 23 (also Amiloride, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Amiodarone and Lithium?
Both drugs can affect the electrical rhythm of your heart. Taking them together increases the risk of a dangerous and irregular heartbeat.
Amiodarone carries more major-labeled pairs than Lithium
SPL source-record counts only. This page's band is moderate · classes on file: Amiodarone (Class III Antiarrhythmic); Lithium (Mood Stabilizer).
Amiodarone has 4 major-labeled pairs vs Lithium's 2. This page itself is in the moderate band, not the major band.
4 major · 9 moderate · 29 minor · 42 total
- Other moderate peers for Amiodarone
- Clarithromycin
- Fluconazole
- Ledipasvir/Sofosbuvir
- Lovastatin
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.