What the FDA labels say about taking them together
Amiodarone and lithium
Amiodarone's FDA label of December 9, 2025 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name amiodarone. The amiodarone label: “Increased risk of Torsade de Pointes. Avoid concomitant use.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the amiodarone label say about lithium?
Amiodarone label, drug interactionsConcomitant Drug/Class/Name: QT Prolonging Drugs; Examples: class I and III antiarrhythmics, lithium, certain phenothiazines, tricyclic antidepressants, certain fluoroquinolone and macrolide antibiotics, azole antifungals, halogenated inhalation anesthetic agents; Clinical Comment: Increased risk of Torsade de Pointes. Avoid concomitant use.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the lithium label say about amiodarone?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name amiodarone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Lithium | |
|---|---|---|
| Labeled for | n/a | Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once