amiodarone vs clonidine
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Side-by-side comparison of amiodarone and clonidine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.
Cordarone, Pacerone
Catapres
Amiodarone (Pacerone) is a medicine used to treat life-threatening, irregular heartbeats. It helps to restore a normal heart rhythm when other medicines don't work or can't be used.
Clonidine (Catapres) is a medicine used to treat high blood pressure. It can be used alone or with other blood pressure medicines.
This medicine treats very fast, irregular heartbeats in the ventricles (lower chambers of the heart). It is used when these irregular heartbeats are life-threatening. It is also used when other medicines don't work well enough or cause too many side effects. This medicine is for adults.
Clonidine is used to treat high blood pressure. High blood pressure can lead to heart disease, stroke, and kidney problems. This medicine helps to lower your blood pressure to a safer level.
Amiodarone affects the electrical signals in your heart. It slows down these signals, which helps your heart beat normally. This medicine can help prevent dangerous, fast heart rhythms.
Clonidine works in the brain to lower blood pressure. It tells your blood vessels to relax and widen. This makes it easier for blood to flow through your body, which lowers blood pressure.
- • Low thyroid levels (hypothyroidism)
- • High thyroid levels (hyperthyroidism)
- • Heart failure
- • Irregular heartbeats
- • Problems with the heart's natural pacemaker (SA node dysfunction)
- • Dry mouth (occurs in about 40 out of 100 people)
- • Drowsiness (occurs in about 33 out of 100 people)
- • Dizziness (occurs in about 16 out of 100 people)
- • Constipation (occurs in about 10 out of 100 people)
- • Feeling sleepy or sedated (occurs in about 10 out of 100 people)
- Dyspnoea 1,158
- Asthenia 975
- Fatigue 895
- Nausea 606
- Cough 597
- Pain 3,038
- Fatigue 2,925
- Nausea 2,920
- Headache 2,798
- Hypertension 2,595
This medicine can cause serious problems with your lungs, liver, and heart. Lung problems can be fatal. Your doctor will check your lungs with X-rays and breathing tests. Liver problems can also be fatal. Your doctor will check your liver with blood tests. This medicine can also make irregular heartbeats worse. You will likely start this medicine in the hospital where your heart can be monitored.
If you suddenly stop taking clonidine, your blood pressure may increase. This can cause serious problems. Talk to your doctor before stopping this medicine.
This medicine can harm your unborn baby. It can cause thyroid problems, slow heart rate, and brain development issues. Do not breastfeed while taking this medicine.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if clonidine will harm your unborn baby. Talk to your doctor if you are breastfeeding.
Also Compare, Nearby Drugs
Compare amiodarone with
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How to Read This amiodarone vs clonidine Comparison
amiodarone is classified in the Class III Antiarrhythmic drug class, while clonidine sits within the Central Alpha-2 Agonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amiodarone has 4,231 submissions while clonidine has 14,276. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both drugs slow down the heart rate. taking them together can make the heart beat too slowly or cause it to stop momentarily.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for amiodarone or clonidine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.