Amiodarone and Atorvastatin Interaction
Drug interaction information between Amiodarone and Atorvastatin.
Amiodarone and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amiodarone and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiodarone causes the level of atorvastatin in your blood to increase, which can raise the risk of side effects.
FDA Label Information
HMG-CoA Reductase Inhibitors simvastatin, lovastatin, atorvastatin Increased plasma concentration of HMG-CoA reductase inhibitor.
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Atorvastatin's 36. In the minor band specifically: Amiodarone has 29 (also Clonidine, Diltiazem, Verapamil, Cyclosporine); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Amiodarone and Atorvastatin?
Amiodarone causes the level of atorvastatin in your blood to increase, which can raise the risk of side effects.
Amiodarone carries more major-labeled pairs than Atorvastatin
SPL source-record counts only. This page's band is minor · classes on file: Amiodarone (Class III Antiarrhythmic); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Amiodarone has 4 major-labeled pairs vs Atorvastatin's 3. This page itself is in the minor band, not the major band.
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Clonidine
- Diltiazem
- Verapamil
- Cyclosporine
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.