Amiodarone and Ezetimibe Interaction
Drug interaction information between Amiodarone and Ezetimibe.
Amiodarone and Ezetimibe have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Amiodarone and Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can cause the cholesterol medicine to build up in your body, which increases the risk of serious muscle damage.
FDA Label Information
Amiodarone, Dronedarone, Ranolazine, or Calcium Channel Blockers Clinical Impact: The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with ezetimibe and simvastatin. For patients taking amiodarone, amlodipine, or ranolazine, do not exceed ezetimibe and simvastatin 10 mg/20 mg daily [see Dosage and Administration ( 2.3 )].
Amiodarone Also Interacts With
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
- Clarithromycin moderate
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Ezetimibe?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Ezetimibe's 25. In the major band specifically: Amiodarone has 4 (also Ezetimibe/Simvastatin, Nirmatrelvir/Ritonavir, Simvastatin); Ezetimibe has 8 (also Amlodipine, Diltiazem, Verapamil, Cyclosporine).
What mechanism field is on file for Amiodarone and Ezetimibe?
Taking these drugs together can cause the cholesterol medicine to build up in your body, which increases the risk of serious muscle damage.
Ezetimibe carries more major-labeled pairs than Amiodarone
SPL source-record counts only. This page's band is major · classes on file: Amiodarone (Class III Antiarrhythmic); Ezetimibe (Cholesterol Absorption Inhibitor).
Ezetimibe has 8 major-labeled pairs vs Amiodarone's 4.
4 major · 9 moderate · 29 minor · 42 total
- Other major peers for Amiodarone
- Ezetimibe/Simvastatin
- Nirmatrelvir/Ritonavir
- Simvastatin
8 major · 4 moderate · 13 minor · 25 total
- Other major peers for Ezetimibe
- Amlodipine
- Diltiazem
- Verapamil
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.