What the FDA labels say about taking them together
Clonidine and haloperidol
Clonidine's FDA label of March 30, 2026 names haloperidol in its drug interactions section; the haloperidol labels PlainMeds reads (2) do not name clonidine. The clonidine label: “Based on observations in patients in a state of alcoholic delirium it has been suggested that high intravenous doses of clonidine may increase the arrhythmogenic potential of high intravenous doses of haloperidol.”
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the haloperidol FDA label on DailyMed (effective April 23, 2026, PD-Rx Pharmaceuticals, Inc.).
What does the clonidine label say about haloperidol?
Clonidine label, drug interactionsBased on observations in patients in a state of alcoholic delirium it has been suggested that high intravenous doses of clonidine may increase the arrhythmogenic potential (QT- prolongation, ventricular fibrillation) of high intravenous doses of haloperidol.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the haloperidol label say about clonidine?
Haloperidol's label (effective April 23, 2026) and its 1 other brand-application label do not name clonidine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Haloperidol), PD-Rx Pharmaceuticals, Inc., effective April 23, 2026 (SPL set 533b0b4c-cbd6-4ec0-a333-8b04b5b43a1d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Haloperidol | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | Schizophrenia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | $15.60 per mL 100 mg/mL vial |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once