Amiodarone and Diltiazem Interaction
Drug interaction information between Amiodarone and Diltiazem.
Amiodarone and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amiodarone and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both work to slow the heart's electrical signals and rhythm. Using them at the same time can cause a dangerously slow heart rate or heart block.
FDA Label Information
Negative Chronotropes digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradine Potentiates the electrophysiologic and hemodynamic effects of amiodarone, resulting in bradycardia, sinus arrest, and AV block.
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Amiodarone's 42. In the minor band specifically: Amiodarone has 29 (also Atorvastatin, Clonidine, Verapamil, Cyclosporine); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Amiodarone and Diltiazem?
These drugs both work to slow the heart's electrical signals and rhythm. Using them at the same time can cause a dangerously slow heart rate or heart block.
Diltiazem's labeled portfolio outnumbers Amiodarone
SPL source-record counts only. This page's band is minor · classes on file: Amiodarone (Class III Antiarrhythmic); Diltiazem (Calcium Channel Blocker).
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Clonidine
- Verapamil
- Cyclosporine
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.