Clonidine and Carvedilol Interaction
Drug interaction information between Clonidine and Carvedilol.
Clonidine and Carvedilol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clonidine and Carvedilol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs lower blood pressure and slow down the heart rate. Taking them together can make these effects too strong, causing a dangerously slow heart or very low blood pressure.
What To Do
Your doctor should monitor your heart rate and blood pressure. If you need to stop these medicines, follow your doctor's specific order to stop the beta-blocker first.
FDA Label Information
( 7.1 , 7.5 ) Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. Concomitant administration of clonidine with a β-blocker may cause hypotension and bradycardia. When concomitant treatment with a β-blocker and clonidine is to be terminated, the β-blocker should be discontinued first.
Clonidine Also Interacts With
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
- Diltiazem minor
Carvedilol Also Interacts With
- Fluoxetine minor
- Paroxetine minor
- Diltiazem minor
- Fluconazole minor
- Verapamil minor
Frequently Asked Questions
Can I take Clonidine and Carvedilol together?
This is a moderate interaction. Your doctor should monitor your heart rate and blood pressure. If you need to stop these medicines, follow your doctor's specific order to stop the beta-blocker first.
How serious is the interaction between Clonidine and Carvedilol?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Clonidine and Carvedilol interact?
Both drugs lower blood pressure and slow down the heart rate. Taking them together can make these effects too strong, causing a dangerously slow heart or very low blood pressure.
Understanding the Clonidine and Carvedilol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Clonidine belongs to the Central Alpha-2 Agonist class and Carvedilol belongs to the Beta-Blocker (Alpha/Beta) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs lower blood pressure and slow down the heart rate. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Clonidine has 29 total documented interactions on file in this dataset, and Carvedilol has 13. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your heart rate and blood pressure. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Clonidine or Carvedilol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.