Clonidine and Carvedilol Interaction
Drug interaction information between Clonidine and Carvedilol.
Clonidine and Carvedilol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clonidine and Carvedilol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs lower blood pressure and slow down the heart rate. Taking them together can make these effects too strong, causing a dangerously slow heart or very low blood pressure.
FDA Label Information
( 7.1 , 7.5 ) Hypotensive agents (e.g., reserpine, MAO inhibitors, clonidine) may increase the risk of hypotension and/or severe bradycardia. Concomitant administration of clonidine with a β-blocker may cause hypotension and bradycardia. When concomitant treatment with a β-blocker and clonidine is to be terminated, the β-blocker should be discontinued first.
Clonidine Also Interacts With
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
- Diltiazem minor
Carvedilol Also Interacts With
- Fluoxetine minor
- Paroxetine minor
- Diltiazem minor
- Fluconazole minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Clonidine + Carvedilol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Carvedilol's 13. In the moderate band specifically: Clonidine has 4 (also Metoprolol, Repaglinide, Sotalol); Carvedilol has 1.
What mechanism field is on file for Clonidine and Carvedilol?
Both drugs lower blood pressure and slow down the heart rate. Taking them together can make these effects too strong, causing a dangerously slow heart or very low blood pressure.
Clonidine's labeled portfolio outnumbers Carvedilol
SPL source-record counts only. This page's band is moderate · classes on file: Clonidine (Central Alpha-2 Agonist); Carvedilol (Beta-Blocker (Alpha/Beta)).
0 major · 4 moderate · 25 minor · 29 total
- Other moderate peers for Clonidine
- Metoprolol
- Repaglinide
- Sotalol
0 major · 1 moderate · 12 minor · 13 total
Carvedilol has no other moderate-band peer in this dataset besides Clonidine.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.