Clonidine and Sotalol Interaction
Drug interaction information between Clonidine and Sotalol.
Clonidine and Sotalol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clonidine and Sotalol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines slow down your heart rate, which can cause your heart to beat too slowly. Additionally, taking them together can cause a dangerous spike in blood pressure if the clonidine is stopped suddenly.
FDA Label Information
7.6 Clonidine Concomitant use with sotalol increases the risk of bradycardia and AV block. Because beta-blockers may potentiate the rebound hypertension sometimes observed after clonidine discontinuation, withdraw sotalol several days before the gradual withdrawal of clonidine to reduce the risk of rebound hypertension.
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Amitriptyline minor
- Diltiazem minor
Sotalol Also Interacts With
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Albuterol minor
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Clonidine + Sotalol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Sotalol's 13. In the moderate band specifically: Clonidine has 4 (also Carvedilol, Metoprolol, Repaglinide); Sotalol has 4 (also Amiodarone, Clarithromycin, Digoxin).
What mechanism field is on file for Clonidine and Sotalol?
Both of these medicines slow down your heart rate, which can cause your heart to beat too slowly. Additionally, taking them together can cause a dangerous spike in blood pressure if the clonidine is stopped suddenly.
Clonidine's labeled portfolio outnumbers Sotalol
SPL source-record counts only. This page's band is moderate · classes on file: Clonidine (Central Alpha-2 Agonist); Sotalol (Class III Antiarrhythmic / Beta-Blocker).
0 major · 4 moderate · 25 minor · 29 total
- Other moderate peers for Clonidine
- Carvedilol
- Metoprolol
- Repaglinide
0 major · 4 moderate · 9 minor · 13 total
- Other moderate peers for Sotalol
- Amiodarone
- Clarithromycin
- Digoxin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.