Amiodarone and Cyclosporine Interaction
Drug interaction information between Amiodarone and Cyclosporine.
Amiodarone and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amiodarone and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiodarone can cause the levels of cyclosporine in your blood to rise. This can lead to kidney problems, even if the dose of cyclosporine is lowered.
FDA Label Information
Cyclosporine Increased plasma levels of cyclosporine have been reported resulting in elevated creatinine, despite reduction of cyclosporine dose. Monitor cyclosporine drug levels and renal function with concomitant use.
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Amiodarone + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Amiodarone's 42. In the minor band specifically: Amiodarone has 29 (also Atorvastatin, Clonidine, Diltiazem, Verapamil); Cyclosporine has 60 (also Adalimumab, Amlodipine, Anidulafungin, Bempedoic Acid).
What mechanism field is on file for Amiodarone and Cyclosporine?
Amiodarone can cause the levels of cyclosporine in your blood to rise. This can lead to kidney problems, even if the dose of cyclosporine is lowered.
Cyclosporine carries more major-labeled pairs than Amiodarone
SPL source-record counts only. This page's band is minor · classes on file: Amiodarone (Class III Antiarrhythmic); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Amiodarone's 4. This page itself is in the minor band, not the major band.
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Clonidine
- Diltiazem
- Verapamil
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amlodipine
- Anidulafungin
- Bempedoic Acid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.