What the FDA labels say about taking them together
Amiodarone and cyclosporine
Amiodarone's FDA label of December 9, 2025 names cyclosporine in its drug interactions section, and cyclosporine's label names amiodarone too. The amiodarone label: “Increased plasma levels of cyclosporine have been reported resulting in elevated creatinine, despite reduction of cyclosporine dose. Monitor cyclosporine drug levels and renal function with concomitant use.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the amiodarone label say about cyclosporine?
Amiodarone label, drug interactionsConcomitant Drug/Class/Name: Cyclosporine; Examples: Increased plasma levels of cyclosporine have been reported resulting in elevated creatinine, despite reduction of cyclosporine dose. Monitor cyclosporine drug levels and renal function with concomitant use.
Source: FDA drug label (Nexterone, NDA022325), Baxter Healthcare Corporation, effective April 16, 2024 (SPL set e9108958-b8d7-4fba-87c3-9a32990de551), via openFDA
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the cyclosporine label say about amiodarone?
Cyclosporine label, drug interactionsnicardipine; itraconazole; clarithromycin; Amiodarone
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Cyclosporine | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $1.04 per unit 0.05% eye emulsion |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once