Clonidine and Diltiazem Interaction
Drug interaction information between Clonidine and Diltiazem.
Clonidine and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clonidine and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medicines slow down the heart, and taking them together can make the heart beat too slowly.
FDA Label Information
Sinus bradycardia resulting in hospitalization and pacemaker insertion has been reported in association with the use of clonidine concomitantly with diltiazem or verapamil.
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Clonidine + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Clonidine's 29. In the minor band specifically: Clonidine has 25 (also Amitriptyline, Verapamil, Haloperidol, Amiodarone); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Clonidine and Diltiazem?
Both medicines slow down the heart, and taking them together can make the heart beat too slowly.
Diltiazem carries more major-labeled pairs than Clonidine
SPL source-record counts only. This page's band is minor · classes on file: Clonidine (Central Alpha-2 Agonist); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Clonidine's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Verapamil
- Haloperidol
- Amiodarone
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.