Carbidopa/Levodopa and Metoclopramide Interaction
Drug interaction information between Carbidopa/Levodopa and Metoclopramide.
Carbidopa/Levodopa and Metoclopramide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carbidopa/Levodopa and Metoclopramide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide blocks the brain receptors that levodopa needs to work, which can make your Parkinson's treatment less effective.
FDA Label Information
7.5 Dopamine D2 Receptor Antagonists Dopamine D2 receptor antagonists (e.g., metoclopramide, phenothiazines, butyrophenones, risperidone) may reduce the therapeutic effects of levodopa.
Carbidopa/Levodopa Also Interacts With
- Warfarin moderate
- Entacapone moderate
- Methyldopa moderate
- Dobutamine moderate
- Dopamine moderate
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Carbidopa/Levodopa + Metoclopramide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoclopramide has 23 labeled pairs on file vs Carbidopa/Levodopa's 13. In the minor band specifically: Carbidopa/Levodopa has 5 (also Risperidone, Erythromycin, Probenecid, Cholestyramine); Metoclopramide has 18 (also Acetaminophen, Cyclosporine, Tetracycline, Atovaquone/Proguanil).
What mechanism field is on file for Carbidopa/Levodopa and Metoclopramide?
Metoclopramide blocks the brain receptors that levodopa needs to work, which can make your Parkinson's treatment less effective.
Metoclopramide carries more major-labeled pairs than Carbidopa/Levodopa
SPL source-record counts only. This page's band is minor · classes on file: Carbidopa/Levodopa (Dopamine Precursor Combination); Metoclopramide (Prokinetic / Antiemetic).
Metoclopramide has 1 major-labeled pair vs Carbidopa/Levodopa's 0. This page itself is in the minor band, not the major band.
0 major · 8 moderate · 5 minor · 13 total
- Other minor peers for Carbidopa/Levodopa
- Risperidone
- Erythromycin
- Probenecid
- Cholestyramine
1 major · 4 moderate · 18 minor · 23 total
- Other minor peers for Metoclopramide
- Acetaminophen
- Cyclosporine
- Tetracycline
- Atovaquone/Proguanil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.