Metoclopramide and Cyclosporine Interaction
Drug interaction information between Metoclopramide and Cyclosporine.
Metoclopramide and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metoclopramide and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide speeds up how fast the stomach empties, which causes the body to absorb cyclosporine more quickly or in larger amounts.
FDA Label Information
digoxin) by metoclopramide, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine).
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Metoclopramide + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Metoclopramide's 23. In the minor band specifically: Metoclopramide has 18 (also Acetaminophen, Tetracycline, Atovaquone/Proguanil, Atropine); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Metoclopramide and Cyclosporine?
Metoclopramide speeds up how fast the stomach empties, which causes the body to absorb cyclosporine more quickly or in larger amounts.
Cyclosporine carries more major-labeled pairs than Metoclopramide
SPL source-record counts only. This page's band is minor · classes on file: Metoclopramide (Prokinetic / Antiemetic); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Metoclopramide's 1. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 18 minor · 23 total
- Other minor peers for Metoclopramide
- Acetaminophen
- Tetracycline
- Atovaquone/Proguanil
- Atropine
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.