Metoclopramide and Tacrolimus Topical Interaction
Drug interaction information between Metoclopramide and Tacrolimus Topical.
Metoclopramide and Tacrolimus Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metoclopramide and Tacrolimus Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide can cause the amount of tacrolimus in your blood to increase. This makes it more likely that you will experience serious side effects from the medication.
FDA Label Information
Other drugs, such as: Magnesium and aluminum hydroxide antacids Metoclopramide May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see Warnings and Precautions ( 5.7 , 5.10 , 5.11 )] .
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tranylcypromine moderate
- Acetaminophen minor
Tacrolimus Topical Also Interacts With
- Omeprazole moderate
- Estradiol moderate
- Diltiazem moderate
- Nifedipine moderate
- Ketoconazole moderate
Frequently Asked Questions
What SPL severity band is on file for Metoclopramide + Tacrolimus Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tacrolimus Topical has 25 labeled pairs on file vs Metoclopramide's 23. In the moderate band specifically: Metoclopramide has 4 (also Lidocaine Topical, Rivastigmine, Tranylcypromine); Tacrolimus Topical has 19 (also Omeprazole, Estradiol, Diltiazem, Nifedipine).
What mechanism field is on file for Metoclopramide and Tacrolimus Topical?
Metoclopramide can cause the amount of tacrolimus in your blood to increase. This makes it more likely that you will experience serious side effects from the medication.
Metoclopramide carries more major-labeled pairs than Tacrolimus Topical
SPL source-record counts only. This page's band is moderate · classes on file: Metoclopramide (Prokinetic / Antiemetic); Tacrolimus Topical (Calcineurin Inhibitor (Topical)).
Metoclopramide has 1 major-labeled pair vs Tacrolimus Topical's 0. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 18 minor · 23 total
- Other moderate peers for Metoclopramide
- Lidocaine Topical
- Rivastigmine
- Tranylcypromine
0 major · 19 moderate · 6 minor · 25 total
- Other moderate peers for Tacrolimus Topical
- Omeprazole
- Estradiol
- Diltiazem
- Nifedipine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.