carbidopa/levodopa vs metoclopramide
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Side-by-side comparison of carbidopa/levodopa and metoclopramide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.5 Dopamine D2 Receptor Antagonists Dopamine D2 receptor antagonists (e.g., metoclopramide, phenothiazines, butyrophenones, risperidone) may reduce the therapeutic effects of levodopa.
Sinemet
Reglan
This medicine contains carbidopa, levodopa, and entacapone. It is used to treat Parkinson's disease.
Metoclopramide is a drug that helps with stomach problems. It can help food move faster through your stomach and reduce nausea.
This medicine treats Parkinson's disease. It can help when other medicines stop working as well near the end of a dose. It can also replace other medicines containing similar ingredients.
This medicine treats heartburn caused by acid reflux when other treatments don't work. It also helps with symptoms of slow stomach emptying in people with diabetes, like nausea, vomiting, and feeling full. This medicine is for adults and should not be used for more than 12 weeks.
Levodopa turns into dopamine in your brain, helping to control movement. Carbidopa helps levodopa get to your brain. Entacapone helps levodopa work longer.
Metoclopramide helps your stomach muscles move faster. This helps food empty from your stomach more quickly. It also blocks a chemical in your brain that causes nausea.
- • Uncontrolled movements
- • Diarrhea
- • Nausea
- • Belly pain
- • Vomiting
- • Restlessness
- • Drowsiness
- • Fatigue
- • Feeling tired
- Fall 4,293
- Seeing or hearing things that are not there 3,733
- Shaking 3,257
- Uncontrolled movements 2,903
- Death 2,727
- Tardive Dyskinesia 13,205
- Extrapyramidal Disorder 11,628
- Nervous System Disorder 7,175
- Dystonia 6,661
- Pain 4,666
This medicine can make you fall asleep suddenly, even when you feel awake. Be careful when driving or doing other activities where you need to be alert. Stopping this medicine suddenly can cause serious problems like fever and confusion.
Metoclopramide can cause a serious movement disorder called tardive dyskinesia. This may not go away even after you stop taking the medicine. The risk of tardive dyskinesia increases with long-term use and high doses. Call your doctor right away if you have uncontrolled muscle movements.
This medicine may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine passes into breast milk.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
How to Read This carbidopa/levodopa vs metoclopramide Comparison
carbidopa/levodopa is classified in the Dopamine Precursor Combination drug class, while metoclopramide sits within the Prokinetic / Antiemetic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, carbidopa/levodopa has 16,913 submissions while metoclopramide has 43,335. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to metoclopramide blocks the brain receptors that levodopa needs to work, which can make your parkinson's treatment less effective.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for carbidopa/levodopa or metoclopramide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.