Carbidopa/Levodopa · larger labeled portfolio than Dobutamine
SPL labels Carbidopa/Levodopa + Dobutamine as moderate; Carbidopa/Levodopa 8 / Dobutamine 1 in that band.
Mechanism on file: These drugs are broken down by the same enzyme, so taking them at the same time can lead to higher drug levels. This can cause dangerous changes in blood pressure or an irregular heartbeat.
FDA SPL severity: Moderate
Carbidopa/Levodopa + Dobutamine · SPL mechanism field
These drugs are broken down by the same enzyme, so taking them at the same time can lead to higher drug levels. This can cause dangerous changes in blood pressure or an irregular heartbeat.
Moderate band excerpt · Carbidopa/Levodopa with Dobutamine
7.2 Drugs Metabolized by Catechol-O-Methyltransferase (COMT) Drugs known to be metabolized by COMT, such as isoproterenol, epinephrine, norepinephrine, dopamine, dobutamine, alpha-methyldopa, apomorphine, isoetherine, and bitolterol should be administered with caution in patients receiving entacapone regardless of the route of administration (including inhalation), as their interaction may result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure [ see Warnings and Precautions (5.10) ].
Carbidopa/Levodopa · 13 SPL pairs (broader portfolio than Dobutamine)
- Dopamine moderate
- Entacapone moderate
- Epinephrine moderate
- Methyldopa moderate
Dobutamine · 1 moderate + 3 total pairs
- Atomoxetine minor
- Propranolol minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.