Carbidopa/Levodopa · larger labeled portfolio than Entacapone
SPL labels Carbidopa/Levodopa + Entacapone as moderate; Carbidopa/Levodopa 8 / Entacapone 2 in that band.
Mechanism on file: Entacapone is designed to block the enzyme that breaks down levodopa, which helps the medicine stay in your system longer. This can increase the effects of the levodopa on your brain and body.
FDA SPL severity: Moderate
Carbidopa/Levodopa + Entacapone · SPL mechanism field
Entacapone is designed to block the enzyme that breaks down levodopa, which helps the medicine stay in your system longer. This can increase the effects of the levodopa on your brain and body.
Moderate band excerpt · Carbidopa/Levodopa with Entacapone
7 DRUG INTERACTIONS Drugs metabolized by COMT: use with caution ( 5.10 , 7.2 ) Anti-hypertensive agents: dose adjustment may be required ( 7.3 ) Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) Drugs that interfere with biliary excretion, glucuronidation and intestinal beta-glucuronidase: dose adjustment of carbidopa, levodopa and...
Carbidopa/Levodopa · 13 SPL pairs (broader portfolio than Entacapone)
- Dobutamine moderate
- Dopamine moderate
- Epinephrine moderate
- Methyldopa moderate
Entacapone · 2 moderate + 3 total pairs
- Tranylcypromine moderate
- Warfarin minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.