Metoclopramide and Rivastigmine Interaction
Drug interaction information between Metoclopramide and Rivastigmine.
Metoclopramide and Rivastigmine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metoclopramide and Rivastigmine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause similar side effects related to muscle control and movement. Taking them together increases the risk of developing shaky movements or muscle stiffness.
FDA Label Information
7 DRUG INTERACTIONS Concomitant use with metoclopramide, beta-blockers, or cholinomimetic and anticholinergic drugs is not recommended (7.1, 7.2, 7.3) 7.1 Metoclopramide Due to the risk of additive extrapyramidal adverse reactions, the concomitant use of metoclopramide and rivastigmine tartrate is not recommended.
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
- Acetaminophen minor
Rivastigmine Also Interacts With
- Atenolol minor
- Oxybutynin minor
- Tolterodine minor
Frequently Asked Questions
What SPL severity band is on file for Metoclopramide + Rivastigmine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoclopramide has 23 labeled pairs on file vs Rivastigmine's 4. In the moderate band specifically: Metoclopramide has 4 (also Lidocaine Topical, Tacrolimus Topical, Tranylcypromine); Rivastigmine has 1.
What mechanism field is on file for Metoclopramide and Rivastigmine?
Both drugs can cause similar side effects related to muscle control and movement. Taking them together increases the risk of developing shaky movements or muscle stiffness.
Metoclopramide carries more major-labeled pairs than Rivastigmine
SPL source-record counts only. This page's band is moderate · classes on file: Metoclopramide (Prokinetic / Antiemetic); Rivastigmine (Acetylcholinesterase Inhibitor).
Metoclopramide has 1 major-labeled pair vs Rivastigmine's 0. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 18 minor · 23 total
- Other moderate peers for Metoclopramide
- Lidocaine Topical
- Tacrolimus Topical
- Tranylcypromine
0 major · 1 moderate · 3 minor · 4 total
Rivastigmine has no other moderate-band peer in this dataset besides Metoclopramide.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.