Metoclopramide and Tranylcypromine Interaction
Drug interaction information between Metoclopramide and Tranylcypromine.
Metoclopramide and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metoclopramide and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these together can cause a severe increase in blood pressure or a dangerous condition called serotonin syndrome. They both change the levels of important chemical messengers in your body.
FDA Label Information
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Acetaminophen minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Metoclopramide + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Metoclopramide's 23. In the moderate band specifically: Metoclopramide has 4 (also Lidocaine Topical, Rivastigmine, Tacrolimus Topical); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Metoclopramide and Tranylcypromine?
Using these together can cause a severe increase in blood pressure or a dangerous condition called serotonin syndrome. They both change the levels of important chemical messengers in your body.
Tranylcypromine carries more major-labeled pairs than Metoclopramide
SPL source-record counts only. This page's band is moderate · classes on file: Metoclopramide (Prokinetic / Antiemetic); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Metoclopramide's 1. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 18 minor · 23 total
- Other moderate peers for Metoclopramide
- Lidocaine Topical
- Rivastigmine
- Tacrolimus Topical
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.