Dopamine · larger labeled portfolio than Carbidopa/Levodopa
SPL labels Carbidopa/Levodopa + Dopamine as moderate; Carbidopa/Levodopa 8 / Dopamine 5 in that band.
Mechanism on file: These medications compete for the same enzyme that clears them from your body. This can cause the drugs to reach high levels, potentially leading to heart rhythm issues or blood pressure spikes.
FDA SPL severity: Moderate
Carbidopa/Levodopa + Dopamine · SPL mechanism field
These medications compete for the same enzyme that clears them from your body. This can cause the drugs to reach high levels, potentially leading to heart rhythm issues or blood pressure spikes.
Moderate band excerpt · Carbidopa/Levodopa with Dopamine
7 DRUG INTERACTIONS Drugs metabolized by COMT: use with caution ( 5.10 , 7.2 ) Anti-hypertensive agents: dose adjustment may be required ( 7.3 ) Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) Drugs that interfere with biliary excretion, glucuronidation and intestinal beta-glucuronidase: dose adjustment of carbidopa, levodopa and...
Carbidopa/Levodopa · 8 moderate + 13 total pairs
- Dobutamine moderate
- Entacapone moderate
- Epinephrine moderate
- Methyldopa moderate
Dopamine · 28 SPL pairs (broader portfolio than Carbidopa/Levodopa)
- Deutetrabenazine moderate
- Digoxin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.