Metoclopramide and Acetaminophen Interaction
Drug interaction information between Metoclopramide and Acetaminophen.
Metoclopramide and Acetaminophen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metoclopramide and Acetaminophen. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Metoclopramide makes your stomach empty faster, which causes the pain reliever to be absorbed into your body more quickly.
What To Do
You should be aware that the pain medicine may work faster or have a stronger effect than normal.
FDA Label Information
digoxin) by metoclopramide, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine).
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
Frequently Asked Questions
Can I take Metoclopramide and Acetaminophen together?
This is a minor interaction. You should be aware that the pain medicine may work faster or have a stronger effect than normal.
How serious is the interaction between Metoclopramide and Acetaminophen?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Metoclopramide and Acetaminophen interact?
Metoclopramide makes your stomach empty faster, which causes the pain reliever to be absorbed into your body more quickly.
Understanding the Metoclopramide and Acetaminophen Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Metoclopramide belongs to the Prokinetic / Antiemetic class and Acetaminophen belongs to the Analgesic / Antipyretic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Metoclopramide makes your stomach empty faster, which causes the pain reliever to be absorbed into your body more quickly. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Metoclopramide has 23 total documented interactions on file in this dataset, and Acetaminophen has 23. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should be aware that the pain medicine may work faster or have a stronger effect than normal. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Metoclopramide or Acetaminophen based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.