Metoclopramide and Acetaminophen Interaction
Drug interaction information between Metoclopramide and Acetaminophen.
Metoclopramide and Acetaminophen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metoclopramide and Acetaminophen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide makes your stomach empty faster, which causes the pain reliever to be absorbed into your body more quickly.
FDA Label Information
digoxin) by metoclopramide, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine).
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
Frequently Asked Questions
What SPL severity band is on file for Metoclopramide + Acetaminophen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Metoclopramide and Acetaminophen tie at 23 labeled pairs each. minor-band counts: Metoclopramide 18 alongside Cyclosporine, Tetracycline, Atovaquone/Proguanil, Atropine; Acetaminophen 21 alongside Acetaminophen/Oxycodone, Carbamazepine, Cidofovir, Codeine.
What mechanism field is on file for Metoclopramide and Acetaminophen?
Metoclopramide makes your stomach empty faster, which causes the pain reliever to be absorbed into your body more quickly.
Metoclopramide carries more major-labeled pairs than Acetaminophen
SPL source-record counts only. This page's band is minor · classes on file: Metoclopramide (Prokinetic / Antiemetic); Acetaminophen (Analgesic / Antipyretic).
Metoclopramide has 1 major-labeled pair vs Acetaminophen's 0. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 18 minor · 23 total
- Other minor peers for Metoclopramide
- Cyclosporine
- Tetracycline
- Atovaquone/Proguanil
- Atropine
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen
- Acetaminophen/Oxycodone
- Carbamazepine
- Cidofovir
- Codeine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.