Carbidopa/Levodopa and Probenecid Interaction
Drug interaction information between Carbidopa/Levodopa and Probenecid.
Carbidopa/Levodopa and Probenecid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carbidopa/Levodopa and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid can interfere with how your body clears levodopa, potentially causing the drug to build up in your system.
FDA Label Information
These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin and chloramphenicol).
Carbidopa/Levodopa Also Interacts With
- Warfarin moderate
- Entacapone moderate
- Methyldopa moderate
- Dobutamine moderate
- Dopamine moderate
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Carbidopa/Levodopa + Probenecid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Carbidopa/Levodopa's 13. In the minor band specifically: Carbidopa/Levodopa has 5 (also Risperidone, Erythromycin, Metoclopramide, Cholestyramine); Probenecid has 23 (also Theophylline, Acetaminophen/Oxycodone, Ampicillin/Sulbactam, Cefazolin).
What mechanism field is on file for Carbidopa/Levodopa and Probenecid?
Probenecid can interfere with how your body clears levodopa, potentially causing the drug to build up in your system.
Probenecid carries more major-labeled pairs than Carbidopa/Levodopa
SPL source-record counts only. This page's band is minor · classes on file: Carbidopa/Levodopa (Dopamine Precursor Combination); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Carbidopa/Levodopa's 0. This page itself is in the minor band, not the major band.
0 major · 8 moderate · 5 minor · 13 total
- Other minor peers for Carbidopa/Levodopa
- Risperidone
- Erythromycin
- Metoclopramide
- Cholestyramine
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Theophylline
- Acetaminophen/Oxycodone
- Ampicillin/Sulbactam
- Cefazolin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.