Carbidopa/Levodopa and Erythromycin Interaction
Drug interaction information between Carbidopa/Levodopa and Erythromycin.
Carbidopa/Levodopa and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carbidopa/Levodopa and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antibiotic can change how your body processes levodopa, which might affect the amount of medicine that gets into your blood.
FDA Label Information
These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin and chloramphenicol).
Carbidopa/Levodopa Also Interacts With
- Warfarin moderate
- Entacapone moderate
- Methyldopa moderate
- Dobutamine moderate
- Dopamine moderate
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Carbidopa/Levodopa + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Carbidopa/Levodopa's 13. In the minor band specifically: Carbidopa/Levodopa has 5 (also Risperidone, Probenecid, Metoclopramide, Cholestyramine); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Carbidopa/Levodopa and Erythromycin?
This antibiotic can change how your body processes levodopa, which might affect the amount of medicine that gets into your blood.
Erythromycin carries more major-labeled pairs than Carbidopa/Levodopa
SPL source-record counts only. This page's band is minor · classes on file: Carbidopa/Levodopa (Dopamine Precursor Combination); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Carbidopa/Levodopa's 0. This page itself is in the minor band, not the major band.
0 major · 8 moderate · 5 minor · 13 total
- Other minor peers for Carbidopa/Levodopa
- Risperidone
- Probenecid
- Metoclopramide
- Cholestyramine
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.