Metoclopramide and Lidocaine Topical Interaction
Drug interaction information between Metoclopramide and Lidocaine Topical.
Metoclopramide and Lidocaine Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metoclopramide and Lidocaine Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines can both lead to a condition where your blood cannot carry oxygen correctly. Taking them at the same time increases the risk of this serious blood disorder.
FDA Label Information
Drugs That May Cause Methemoglobinemia When Used with LIDODERM Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia : Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea,...
Metoclopramide Also Interacts With
- Posaconazole major
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
- Acetaminophen minor
Lidocaine Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Valproate moderate
- Chloroquine moderate
- Mexiletine moderate
Frequently Asked Questions
What SPL severity band is on file for Metoclopramide + Lidocaine Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoclopramide has 23 labeled pairs on file vs Lidocaine Topical's 10. In the moderate band specifically: Metoclopramide has 4 (also Rivastigmine, Tacrolimus Topical, Tranylcypromine); Lidocaine Topical has 10 (also Acetaminophen, Nitrofurantoin, Valproate, Chloroquine).
What mechanism field is on file for Metoclopramide and Lidocaine Topical?
These medicines can both lead to a condition where your blood cannot carry oxygen correctly. Taking them at the same time increases the risk of this serious blood disorder.
Metoclopramide carries more major-labeled pairs than Lidocaine Topical
SPL source-record counts only. This page's band is moderate · classes on file: Metoclopramide (Prokinetic / Antiemetic); Lidocaine Topical (Topical Anesthetic).
Metoclopramide has 1 major-labeled pair vs Lidocaine Topical's 0. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 18 minor · 23 total
- Other moderate peers for Metoclopramide
- Rivastigmine
- Tacrolimus Topical
- Tranylcypromine
0 major · 10 moderate · 0 minor · 10 total
- Other moderate peers for Lidocaine Topical
- Acetaminophen
- Nitrofurantoin
- Valproate
- Chloroquine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.