Metoclopramide and Lidocaine Topical Interaction
Drug interaction information between Metoclopramide and Lidocaine Topical.
Metoclopramide and Lidocaine Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Metoclopramide and Lidocaine Topical. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These medicines can both lead to a condition where your blood cannot carry oxygen correctly. Taking them at the same time increases the risk of this serious blood disorder.
What To Do
Watch for symptoms like a fast heartbeat, headache, or bluish skin color. Tell your healthcare provider if you are using both of these treatments.
FDA Label Information
Drugs That May Cause Methemoglobinemia When Used with LIDODERM Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia : Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea,...
Metoclopramide Also Interacts With
- Posaconazole major
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
- Acetaminophen minor
Lidocaine Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Valproate moderate
- Chloroquine moderate
- Mexiletine moderate
Frequently Asked Questions
Can I take Metoclopramide and Lidocaine Topical together?
This is a moderate interaction. Watch for symptoms like a fast heartbeat, headache, or bluish skin color. Tell your healthcare provider if you are using both of these treatments.
How serious is the interaction between Metoclopramide and Lidocaine Topical?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Metoclopramide and Lidocaine Topical interact?
These medicines can both lead to a condition where your blood cannot carry oxygen correctly. Taking them at the same time increases the risk of this serious blood disorder.
Understanding the Metoclopramide and Lidocaine Topical Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Metoclopramide belongs to the Prokinetic / Antiemetic class and Lidocaine Topical belongs to the Topical Anesthetic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These medicines can both lead to a condition where your blood cannot carry oxygen correctly. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Metoclopramide has 23 total documented interactions on file in this dataset, and Lidocaine Topical has 10. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Watch for symptoms like a fast heartbeat, headache, or bluish skin color. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Metoclopramide or Lidocaine Topical based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.