Carbidopa/Levodopa and Cholestyramine Interaction
Drug interaction information between Carbidopa/Levodopa and Cholestyramine.
Carbidopa/Levodopa and Cholestyramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Carbidopa/Levodopa and Cholestyramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cholestyramine can stick to levodopa in your digestive tract and stop it from being absorbed into your bloodstream.
FDA Label Information
These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin and chloramphenicol).
Carbidopa/Levodopa Also Interacts With
- Warfarin moderate
- Entacapone moderate
- Methyldopa moderate
- Dobutamine moderate
- Dopamine moderate
Cholestyramine Also Interacts With
- Naproxen moderate
- Olmesartan moderate
- Raloxifene moderate
- Propranolol minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Carbidopa/Levodopa + Cholestyramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cholestyramine has 34 labeled pairs on file vs Carbidopa/Levodopa's 13. In the minor band specifically: Carbidopa/Levodopa has 5 (also Risperidone, Erythromycin, Probenecid, Metoclopramide); Cholestyramine has 31 (also Propranolol, Warfarin, Tetracycline, Phenobarbital).
What mechanism field is on file for Carbidopa/Levodopa and Cholestyramine?
Cholestyramine can stick to levodopa in your digestive tract and stop it from being absorbed into your bloodstream.
Cholestyramine's labeled portfolio outnumbers Carbidopa/Levodopa
SPL source-record counts only. This page's band is minor · classes on file: Carbidopa/Levodopa (Dopamine Precursor Combination); Cholestyramine (Bile Acid Sequestrant).
0 major · 8 moderate · 5 minor · 13 total
- Other minor peers for Carbidopa/Levodopa
- Risperidone
- Erythromycin
- Probenecid
- Metoclopramide
0 major · 3 moderate · 31 minor · 34 total
- Other minor peers for Cholestyramine
- Propranolol
- Warfarin
- Tetracycline
- Phenobarbital
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.